CD11b Ly-6C Suppressive Monocytes in Experimental Autoimmune Encephalomyelitis
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چکیده
منابع مشابه
CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis.
Innate immune cells may regulate adaptive immunity by balancing different lineages of T cells and providing negative costimulation. In addition, CD11b(+)Gr-1(+) myeloid-derived suppressor cells have been described in tumor, parasite infection, and severe trauma models. In this study, we observe that splenic CD11b(+) cells markedly increase after experimental autoimmune encephalomyelitis (EAE) i...
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CD11b + Ly-6C hi cells, including inflammatory monocytes (IMCs) and inflammatory dendritic cells (IDCs), are important in infectious , autoimmune, and tumor models. However, their role in T cell regulation is controversial. In this article, we show that T cell regulation by IMCs and IDCs is determined by their activation state and is plastic during an immune response. Non-activated IMCs and IDC...
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متن کاملOUTSTANDING OBSERVATION Naı̈ve blood monocytes suppress T-cell function. A possible mechanism for protection from autoimmunity
In certain disease context, cells of the monocyte/macrophage lineage are known to exhibit T-cell suppressor function. However, whether naı̈ve monocytes are also able to suppress T-cell responses has not been previously investigated. In this study, we have discovered that CD11b+Ly6G mononuclear cells in the blood of naı̈ve mice are potent suppressors of T-cell proliferation in vitro. The suppressi...
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